ELRIG-Forum 2018: Abstracts
Martina Hampel, Fraunhofer, IPA, Stuttgart, Germany
Laboratories will evolve to high complex data factories, which are integrated into the value added system of each company. Data, Knowledge and product quality are all assured in a laboratory environment and all this data will become more important in the future due to personalization and digitalization.
Ralf Kettenhofen, Ncardia, Köln, Germany
Drug development projects in the pharma industry are focused on efficacy screening for the target of interest. But often compounds fail due to safety issues in costly late-stage safety pharmacological studies. For that reason, high throughput sodium, calcium and hERG ion channel binding assays and automated patch clamp of recombinant cell lines expressing the human ion channels were implemented.
Kristina Nehlsen, InSCREENeX GmbH, Braunschweig, Germany
Epithelial cells from organs like skin, intestine or lung form a tight barrier. The physiological role of this barrier is to prevent foreign organisms/substances to penetrate the body. As drug delivery through this barrier is of uttermost importance, in vitro test systems are highly desirable that mimic the in vivo situation. Such a cell system will reflect the barrier properties with regard to passive and active transport processes and in addition should produce mucus, a glycoprotein complex that protects the epithelial cells and thus the respective barrier.
Ingo Kober, Merck, Darmstadt, Germany
In 2017 Merck further broadened its comprehensive hit identification platform by integrating DNA encoded Library Screening in collaboration with the Copenhagen based CRO Vipergen. DNA-encoded libraries (DELs) are pools of DNA-tagged small molecules that enable facile screening of pools of millions of compounds for binding to a protein target. Other than in classical HTS, parallel full deck screening under several conditions, varying stringency or challenging selectivity comes at little additional effort.
Tim Stroud, Titian Software, London, UK
Life sciences research and development can generate an almost endless variety of samples and materials which need to be stored, tracked and managed. Accurate tracking of this inventory may be critical to the value of any experimental results but presents an ever-increasing challenge with the rising throughputs of modern biological research.
