Edgar Specker, FMP, Berlin-Buch

The compound management as part of the MedChem group at the Leibniz Institut für Molekulare Pharmakologie (FMP) assures optimal control quality and identity of each compound in the screening library. Thereto a routine and robust procedure was developed which ensures a qualified assessment of compounds in terms of their purity and stability. Compounds are transferred via SOP´s to the automated storage system (KIWI Store from Liconic AG). If compounds were identified as hits in the primary screen a new batch of compounds could be ordered and used for the validation in the hit picking process. A small aliquot is separated from the hit picking plates and measured via LC-MS. The qualitative and quantitative analysis by means of UV and MS spectroscopy is an important feature for the evaluation and confirmation of a selected hit.

Kerstin Thurow, Center for Life Science Automation, Uni Rostock

Automation systems with applied robotics have already been established in industrial applications for many years. In the field of life sciences, a comparable high level of automation can be found in the areas of bio screening as well as high-throughput screening. Strong deficits still exist in the development of flexible and universal fully automated systems in the field of analytical measurement. Reasons are the heterogeneous processes with complex structures, which include sample preparation and transport, analytical measurements using complex sensor systems as well as suitable data analysis and evaluation.

Mario Bott, IPA Fraunhofer Stuttgart

Liquid handling is the key process in virtual all life science procedures and the automation of liquid transfer represents a major challenge. In the light of increased assay throughputs and savings in costs and reagents, miniaturized process layouts have gained increasing importance. We will present the flexible and cost effective application of fluid handling in the nanoliter range in the field of biomarker screening.

Mustapha Hidri, Merck KGaA, Darmstadt
Daniel Serra, Chemspeed Technologies, Augst, Schweiz

Merck's compound library contains more than 1,000,000 Small Molecules. Most of them are in solid form and have to be delivered in milligram scale fractions for intern and extern biological tests. Due to the substances variety, the small available quantities and the continuous demand, is a clean dispense in short time a big challenge by the compound management.

Tobias May, InSCREENeX GmbH, Braunschweig, Germany

Introduction
A major limitation of current research is the shortage of physiologically relevant cells. To generate cells in sufficient numbers in vitro cell expansion is an attractive alternative. We developed an immortalization regimen allowing the efficient and reproducible establishment of novel cell lines. The technology allows the generation of cell lines from different cell types, from different species and from different donors.

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