Unter der Annahme, dass „substance“ benötigt wird und „testing“ benötigt wird, wurden folgende Ergebnisse gefunden:

  • Abstract Lab 4.0 – Future trends in life sciences (the cloud lab)

    Martina Hampel, Fraunhofer, IPA, Stuttgart, Germany Laboratories will evolve to high complex data factories, which are integrated into the value added system of each company. Data, Knowledge and product quality are all assured in a laboratory...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/236-hampel-abs10

  • Human induced pluripotent stem cell-derived cardiomyocytes - Case studies for the application in early drug development

    Ralf Kettenhofen, Ncardia, Köln, Germany Drug development projects in the pharma industry are focused on efficacy screening for the target of interest. But often compounds fail due to safety issues in costly late-stage safety pharmacological studies....

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/235-kettenhofen-abs9-3

  • Creating functional barriers in vitro. Lessons from lung and gut

    Kristina Nehlsen, InSCREENeX GmbH, Braunschweig, Germany Epithelial cells from organs like skin, intestine or lung form a tight barrier. The physiological role of this barrier is to prevent foreign organisms/substances to penetrate the body. As drug...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/233-nehlsen-abs8

  • Hit identification strategy at Merck: DELT

    Ingo Kober, Merck, Darmstadt, Germany In 2017 Merck further broadened its comprehensive hit identification platform by integrating DNA encoded Library Screening in collaboration with the Copenhagen based CRO Vipergen. DNA-encoded libraries (DELs) are...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/232-kober-abs7

  • Accurate biological sample tracking – benefits, challenges and considerations

    Tim Stroud, Titian Software, London, UK Life sciences research and development can generate an almost endless variety of samples and materials which need to be stored, tracked and managed. Accurate tracking of this inventory may be critical to the...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/230-stroud-abs5

  • Integrated Data and Workflow Management in High-throughput Cell Line Screening

    Christoph Freiberg, GenData, Basel, Schweiz We have implemented a dedicated cell line development platform for automating the generation, selection, and assessment of mammalian cell lines. By centrally capturing and processing all data along the CLD...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/229-freiberg-abs4

  • Hit Identification Strategy at Merck: High Throughput MALDI-TOF

    Martin Hoffmann, Merck, Darmstadt, Germany In recent times mass spectrometry detection was established as label-free alternative for the detection of substrates and products in enzyme reaction, which were run in high throughput screening. Advances in...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/237-hoffmann-abs11

  • Semi-automated Reception and Processing of Patient Samples for the Production of an individualized Vaccine

    Christine Hawner, BioNtech, Mainz, Germany Every tumor has an exclusive pattern of tumor antigens which are based on acquired mutations. Even within the same type of cancer, only a small percentage of mutations is shared, most of them are absolutely...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/226-hawner-abs

  • Innovations in Antibiotic Related Drug Discovery

    Andreas Vilcinskas, Institute for Insect Biotechnology, Justus Liebig-University Giessen, Germany, Fraunhofer Institute for Molecular Biology and Applied Ecology, Department Bioressources, Giessen, Germany The increasing prevalence of human pathogens...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/225-vilcinskas-abs

  • Abstract of talk entitled “The Yin and Yang of CRISPR Screening: A Dual Approach to Revolutionize Drug Discovery “

    Jochen Hartner, Horizon Discovery Ltd, UK Functional genomic screening with CRISPR–Cas9 has provided a powerful and precise new way to interrogate the phenotypic consequences of gene manipulation in high-throughput, unbiased analyses. Rapid development...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/224-hartner-abs6

  • Screening and profiling of cancer therapeutics in primary and stem cell-derived Human 3D Tissues

    Bram Herpers, OcellO B.V., Leiden, The Netherlands OcellO develops and uses clinically relevant in vitro human tissue models for screening and profiling of small molecules and biologics. Tissues cultured in a natural 3D extracellular matrix environment...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2017/forum2017-abstracts/190-herpers-abs

  • Cellshare – a Cloud-Lab for cell-based assays

    Lena Schober, Moriz Walter, Andrea Traube, Fraunhofer Institute for Manufacturing Engineering and Automation IPA, Department Laboratory Automation and Biomanufacturing Engineering, Stuttgart The use of cell-based assays in pharmaceutical industry and...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2017/forum2017-abstracts/189-schober-walter-traube-abs

  • High throughput solutions for cardiac drug and safety research

    Elena Dragicevic, Nanion Technologies In the ever-evolving world of safety pharmacology, adequate tools and strategies are not only preferred but necessary. Ion channels have long been targets for various safety testing. However, other proteins...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/270-dragicevic-abs19

  • Novel recombinant Cytomegaloviruses allow screening of three dynamic stages of lytic infection from population to single-cell level

    Ulfert Rand, Helmholtz Centre for Infection Research, Braunschweig A highly dynamic gene activation process begins upon entry of CMV genomes into the host cell nucleus, both on the viral and on the host-cell side. The timing and velocity of gene...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/278-rand-abs19

  • MS-based chemoproteomics approaches for target identification and validation

    Stefan Müller, Evotec Evotec’s chemoproteomic approaches to deconvolute target proteins of small molecules are unbiased, address the entire cellular proteome, and are applicable in various organisms. Target proteins are analysed by quantitative mass...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/277-mueller-abs19

  • CETSA® enabled Drug Discovery

    Michael Dabrowski, Pelago Bioscience CETSA allows physiological relevant quantification of target engagement, which is prerequisite for achieving the intended efficacy. Therefore CETSA has during the last 8 years been applied from early target...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/276-dabrowski-abs19

  • Energy transfer as a general approach to assess target occupancy and residence time for kinase inhibitors and PROTACs in living cells

    Matt Robers, Promega We will describe the application of an energy transfer technique (NanoBRET) that enables the first live cell approach to broadly profile compound fractional occupancy and residence time against a variety of target classes including...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/275-robers-abs19

  • Advanced Biological Screening

    Holger Erfle, Ruprecht-Karls-Universität Heidelberg Delivery of large and functionally active biomolecules across cell membranes is a challenge, particularly for high-throughput experiments. For this purpose, we developed a novel solid-phase reverse...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/274-erfle-abs19

  • Target Identification and Validation using CRISPR Technology

    Hauke Cornils, Evotec Phenotypic screening approaches provide the possibility to identify novel small molecules based on the desired cellular effects in an unbiased fashion. However, despite progress in the development and analysis of phenotypic...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/273-cornils-abs19

  • Proteomics for target and pathway deconvolution

    Hannes Hahne, OmicScouts Preclinical stages in the drug discovery process require a multitude of biochemical and genetic assays in order to characterize the effects of drug candidates on cellular systems and model organisms. The identification and...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/272-hahne-abs19

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