Unter der Annahme, dass „potency“ benötigt wird und „assays“ benötigt wird, wurden folgende Ergebnisse gefunden:

  • Automation of Potency Assays: it’s not plug-and-play, it’s a journey

    and targets and some of the different questions and challenges which appeared when setting-up automation solutions for potency assays under GMP-conditions. E.g., which factors we consider relevant for optimal use of automation systems for potency assays...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2020/forum2020-abstracts/298-beck-abs20

  • From sample to Result - Full-Automation of Potency Assays

    Katharina Künzel, Boehringer Ingelheim Pharma, Analytical Dev. Biologicals, Biberach, Germany Potency assays such as cell-based bioassays as well as ELISA binding assays are employed for release and stability testing of biologics and to study their...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2020/forum2020-abstracts/305-kuenz-abs20

  • Activity is the key - Development of potency assays for biologics

    W. Alexander Mengel, AbbVie Deutschland GmbH & Co. KG, Analytical R&D, Germany Cell based potency assays (bioassays) are a central element of the analytical control strategy of biologics since they are the only method capable of testing a drug´s effect...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2020/forum2020-abstracts/306-menge-abs20

  • A Novel Approach to Quantify Target Engagement in Live Cells

    Dr. Stephan Kirchmaier, Promega, Walldorf Confirming that a compound binds its intended target within living cells is essential for successful drug discovery yet remains technically challenging for novel or poorly characterized proteins. Traditional...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2026/forum2026-abstracts/471-abstract-kirchmaier-promega-26

  • Energy transfer as a general approach to assess target occupancy and residence time for kinase inhibitors and PROTACs in living cells

    Matt Robers, Promega We will describe the application of an energy transfer technique (NanoBRET) that enables the first live cell approach to broadly profile compound fractional occupancy and residence time against a variety of target classes including...

    https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/275-robers-abs19

Ergebnisse 1 - 5 von 5

pfeil zurueck pfeil top