Deconvoluting the Drivers of Targeted Protein Degradation

Kristin Richling, Promega, USA Targeted protein degradation is a promising new therapeutic strategy consisting of small molecules, most commonly molecular glues or Proteolysis Targeting Chimeras (PROTACs), which elicit degradation of a target protein....

Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization

Martin Schwalm, Inst. F. Biochemie, Uni Frankfurt PROteolysis TArgeting Chimeras (PROTACs) are chimeric molecules to induce the multistep degradation process of a protein of interest through the ubiquitin proteasomal system (UPS). Despite PROTACs are...

Targeted protein degradation & protein proximity – a journey from high throughput screening to developing drugs for the ‘undruggable’ proteome

Dr. Alexander Hergovich, Toulouse, France Targeted protein degradation (TPD) and the targeting of protein-protein interactions (PPIs) in a wider sense have emerged as novel drug discovery and development avenues. These approaches can tackle...

ELRIG-Forum 2026 Programm

from Lab to Data 08:00 08:45 Registration 08:50 09:00 Welcome by the ELRIG.de e.V. Richard Rösch 09:00 09:40 Targeted protein degradation & protein proximity – a journey from high throughput screening to developing drugs for the ‘undruggable’ proteome....

Enabling effective data management for PROTAC development

Emilia Hietala, CCD Vault, UK PROteolysis TArgeting Chimeras (PROTACs) are chimeric molecules to induce the multistep degradation process of a protein of interest through the ubiquitin proteasomal system (UPS). Despite PROTACs are from rising interest...

Applying a „first principle“ biophysical method for Targeted Protein degradation

Hedeby Hasse, Fido Biosystems Applying a „first principle“ biophysical method for Targeted Protein degradation” We assist you realizing the full potential of your complex biology beyond current technologies Our Fidabio instruments are aimed at...

Mechanistic Insights on Molecular Glue Degraders

Grasilda Zenkeviciute, Proxygen, Wien Targeted protein degradation (TPD) is emerging as an important approach in pharmaceutical research and holds potential for changing the scope of drugs by enabling the targeting of proteins previously deemed...

Licence to eliminate- Protein degraders @ Merck

Carola Sparn/Birgitta Leuthner, Merck, Darmstadt Targeted protein degradation can remove disease-causing proteins from the organism by hijacking the cells own proteasomal degradation mechanism. Thus, it is an attractive therapeutic option whenever mere...

2026

PRISKA: Integrated screening- and knowledge-platform for molecular degrader

Johanna Huchting, Fraunhofer ITMP, Hamburg Targeted protein degradation (TPD) is a highly promising modality for novel therapeutics where, in contrast to traditional drugs that stoichiometrically inhibit protein function, molecular degraders...

Goethe-Universität Frankfurt am Main (PROXIDRUGS)

by Goethe University Frankfurt that researches and develops proximity‑induced drugs which harness cellular protein degradation machinery to selectively eliminate disease‑relevant proteins, aiming to open new therapeutic avenues and support commercial...

Pelobiotech

stem cells, diseased cells and 2D&3D cell culture systems. Choose from a range of 18,000 products including Targeted Protein Degradation tools and customized solutions with a choice of prime media in R&D, GMP-like and GMP quality plus xeno-free,...

Deep proteomic screening for systematic discovery of degrader targets and mechanisms

Henrik Daub, NEOsphere Biotechnologies GmbH, Martinsried, Germany Targeted protein degradation (TPD) is a breakthrough therapeutic approach to eliminate disease-relevant proteins previously considered undruggable. Established degrader drugs that...