Mechanistic Insights on Molecular Glue Degraders

holds potential for changing the scope of drugs by enabling the targeting of proteins previously deemed undruggable. Molecular Glue Degraders (MGDs) induce a ternary complex through protein–protein interactions between a ubiquitin ligase and a target...

PRISKA: Integrated screening- and knowledge-platform for molecular degrader

the modular design of the bRo5 hetero-bivalent PROTAC-prototype. Rational approaches for the discovery of monovalent molecular glue (MG)-type degraders are beginning to emerge; yet, clinical success for non-serendipitous MG degraders is still lagging...

Deep proteomic screening for systematic discovery of degrader targets and mechanisms

come mainly in two varieties: heterobifunctional molecules also known as PROTACs (PROteolysis TArgeting Chimeras) or molecular glue compounds. Systematic discovery of novel molecular glues and their cellular degradation targets has so far been...

ProxiCapture: A Platform for the Discovery of CRBN Binders via MS-Based Protein Interaction Profiling

Dr. Thorsten Mosler, Leader Proximity Proteomics, Uni Frankfurt Molecular glue degraders represent a rapidly expanding class of small molecules that reprogram E3 ubiquitin ligases to ubiquitinate and degrade disease-relevant proteins. Despite their...

ELRIG-Forum 2026 Programm

Small Molecules and Biologics – from Lab to Data 08:00 08:45 Registration 08:50 09:00 Welcome by the ELRIG.de e.V. Richard Rösch 09:00 09:40 Targeted protein degradation & protein proximity – a journey from high throughput screening to developing drugs...

2026

Licence to eliminate- Protein degraders @ Merck

and optimize active compounds. Here, we are focusing on two different modalities, the bifunctional degraders and the molecular glue degraders. This talk will give an insight into how biochemical as well as cell-based assays are utilized to screen...