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Hit identification strategy at Merck: DELT
Ingo Kober, Merck, Darmstadt, Germany In 2017 Merck further broadened its comprehensive hit identification platform by integrating DNA encoded Library Screening in collaboration with the Copenhagen based CRO Vipergen. DNA-encoded libraries (DELs) are...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/232-kober-abs7 -
Accelerating Merck's DMTA Cycle with Lab Digitalization and Automation
Sebastian Fuchs, Merck KGaA, Darmstadt At Merck Healthcare, we are working on the acceleration of the Design-Make-Test-Analyze (DMTA) cycle through comprehensive digitalization and automation. We highlight the use of Genedata Screener for automated...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2025/forum2025-abstracts/450-abstract-fuchs-merck-kgaa-25 -
Lab Instrument Data Integration using MTP
Christian Schäfer, Merck KGaA, Merck Electronics, Darmstadt In the laboratory, we face the challenge that digital aspects are often present in system-specific data structures, while measurements are frequently available without context. Access to this...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2026/forum2026-abstracts/473-abstract-schaefer-merck-26 -
ELRIG-Forum 2026 Programm
CBmed, Graz 13:50 14:10 High-Throughput-Experimentation: Boosting Productivity & Reproducibility via Automation Nico Fleck Merck, Darmstadt 14:10 14:30 Automation and AI-Driven Process Optimization in cell and gene therapy manufacturing Laura Herbst...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2026/forum2026-programm -
Hit Identification Strategy at Merck: High Throughput MALDI-TOF
Martin Hoffmann, Merck, Darmstadt, Germany In recent times mass spectrometry detection was established as label-free alternative for the detection of substrates and products in enzyme reaction, which were run in high throughput screening. Advances in...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/237-hoffmann-abs11 -
Licence to eliminate- Protein degraders @ Merck
Carola Sparn/Birgitta Leuthner, Merck, Darmstadt Targeted protein degradation can remove disease-causing proteins from the organism by hijacking the cells own proteasomal degradation mechanism. Thus, it is an attractive therapeutic option whenever mere...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2023/forum2023-abstracts/377-sparn-abs-23-3 -
„Opportunities and Challenges of Digitalized Lab Data Management“
Arne Kusserow, Merck KGaA, Darmstadt Many aspects of digitalization are discussed for years and years. Many initiatives for standardization were established and failed to set proper “standards”. Meanwhile the demand for better data increased, but the...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2025/forum2025-abstracts/447-abstract-kusserow-merck-kgaa-25 -
High-Throughput-Experimentation: Boosting Productivity & Reproducibility via Automation
Dr. Nico Fleck, Associate Director, Head of High-Throughput Experimentation & Catalysis, Merck Electronics KGaA The complexity of scientific questions certainly skyrocketed in the past decades and this trend is certainly fueled by rising capabilities...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2026/forum2026-abstracts/476-abstract-fleck-merck-26 -
qPCR automation – connecting drug discovery and COVID-19 testing.
Katrin Beeman, Merck KGaA, Darmstadt The quantification of gene expression is an essential step to understand the function of a gene in a physiological context. In recent years transcriptomic solutions have been developed to investigate the gene...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2021/forum2021-abstracts/336-bee-abs21 -
Automation-enabled assay development for high throughput screening
Nina Grossmann, Discovery Pharmacology, Merck, Darmstadt, Germany At Merck, a proprietary library of roughly 1 Mio drug like compounds is screened in 10-15 HTS campaigns per year. Respective assays range from simple binding analysis to complex...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2020/forum2020-abstracts/319-gross-abs20 -
The 3rd dimension – bridge between in vitro & in vivo
Sakshi Garg, Merck, Darmstadt Over the last decades, data has emerged highlighting that conventional 2D cell culture tumor models fail to capture important aspects of tumor physiology such as the delicate microenvironment, cell-cell communication,...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2017/forum2017-abstracts/184-garg-abs -
ELRIG-Forum 2025 Programm
Ribbon Bio, Wien, Austria 13:40 14:00 Opportunities and Challenges of Digitalized Lab Data Management ArneKusserow Merck KGaA, Darmstadt 14:00 14:20 Der Cyber Resilience Act: Anforderungen und Auswirkungen auf vernetzte Produkte Martin Neumann Infoteam,...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2025/forum2025-programm -
First True 1:1 Gravimetric Pick and Dispense of Solids
Mustapha Hidri, Merck KGaA, Darmstadt Daniel Serra, Chemspeed Technologies, Augst, Schweiz Merck's compound library contains more than 1,000,000 Small Molecules. Most of them are in solid form and have to be delivered in milligram scale fractions for...
https://www.elrig.de/index.php/25-veranstaltungen/elrig-foren/abstracts/abstracts-2016/156-hidri-sera-abs -
Instrument Connectivity – all data in one place using AnIML
Arne Kusserow Merck BSSN, Darmstadt Laboratories produce scientific data. This is their basic purpose. Today, only a small fraction of the produced data is used. The vast majority of data, including most metadata are not used and are not even...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2021/forum2021-abstracts/342-kuss-abs21 -
Drug discovery using kinetic live cell imaging of primary human cells
Enrico Schmidt, Merck KGaA, Novartis, Basel, Switzerland Cellular behavior is tightly regulated by multiple pathways both in space and time. Modulation of all cellular mechanisms can therefore not only be achieved by targeted delivery of modulator to...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2017/forum2017-abstracts/173-schmidt-abs
