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Target Identification and Validation using CRISPR Technology
targets. Genetic screening approaches allow bridging phenotypic and target-based drug discovery approaches. Especially the CRISPR system with its potential to induce loss of functions mutations offers the possibility to identify and validate novel...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/273-cornils-abs19 -
Forum 2026 Vorwort
zu entwickeln, um neue Therapien zu erforschen. Die Fortschritte in Bereichen wie 3D Zell- und Organoidkultur, ADCs, CRISPR, PROTACs, Next Generation Sequencing, hochauflösende Mikroskopie sowie weitere neue Technologien erweitern die Möglichkeiten der...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2026/forum2026-vorwort -
Abstract of talk entitled “The Yin and Yang of CRISPR Screening: A Dual Approach to Revolutionize Drug Discovery “
Jochen Hartner, Horizon Discovery Ltd, UK Functional genomic screening with CRISPR–Cas9 has provided a powerful and precise new way to interrogate the phenotypic consequences of gene manipulation in high-throughput, unbiased analyses. Rapid development...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2018/forum2018-abstracts/224-hartner-abs6 -
Vivlion GmbH
Vivlion is a CRISPR‑focused biotech CRO and Goethe University Frankfurt spin‑out that provides next‑generation gene‑editing reagents and CRISPR screening services based on its proprietary 3Cs technology, offering uniform and combinatorial CRISPR...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2026/forum2026-fkb/514-vivlion-kbs-26 -
Extracting Active UPS Complexes from Combinatorial Genetics Data
provides a powerful route to uncover functional gene networks and actionable vulnerabilities. While single-gene CRISPR screens identify essential genes, they fail to resolve buffering relationships, paralog dependencies, and higher-order pathway...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2026/forum2026-abstracts/497-abstract-kaulich-vivlion-26 -
ELRIG-Forum 2026 Programm
Small Molecules and Biologics – from Lab to Data 08:00 08:45 Registration 08:50 09:00 Welcome by the ELRIG.de e.V. Richard Rösch 09:00 09:40 Targeted protein degradation & protein proximity – a journey from high throughput screening to developing drugs...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2026/forum2026-programm -
High-throughput screening and target deconvolution of novel oncogenic signaling pathway inhibitors
using a cellular YAP1/TAZ reporter assay. Target deconvolution studies, including cellular thermal shift assays and CRISPR/Cas9-KO screens identified PGGT1B, a subunit of the geranylgeranyltransferase‑I (GGTase‑I) complex, as the direct target of...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2021/forum2021-abstracts/353-lang-abs21 -
Advanced Biological Screening
of the method, ranging from antibody-mediated protein localization and antibody-mediated inhibition of protein function to CRISPR/Cas9 based gene editing in living cells. The method is scalable to high-throughput and enables pre-fabrication of “ready to...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2019/forum2019-abstracts/274-erfle-abs19 -
Bringing technology to the biology to tackle human, animal and plant health challenges
networks. Emphasis is on using 3D models, patient material, multicellular tissues, organoids, iPSC-derived models and CRISPR/Cas9, using multi-parametric phenotypic readouts where appropriate. We are also building a similar consortium in crop protection...
https://www.elrig.de/index.php/elrig-foren/elrig-forum-2017/forum2017-abstracts/187-andrews-abs
