André Frenzel, YUMAB GmbH, Braunschweig,Germany
Antibody phage display has been used for the discovery of therapeutic antibodies since decades. Although several alternative technologies have been developed in the meantime such as single B-cell cloning from immunized donors or transgenic animals expressing a human antibody repertoire, antibody phage display still provides a powerful technology for therapeutic programs. In vitro technologies can be combined with other technologies such as immunization to allow loss-free preservation of the immune repertoire of immunized animals or specific patient groups. The availability of large data sets of expressed antibodies allows bioinformatic assisted prediction of developability to simplify lead selection.